CBG (Cannabigerol) 101

Everything You Need To Know About CBG

CBG or cannabigerol is one of the active compounds which are known as cannabinoids and found in the cannabis plant. Most people know about the cannabinoids THC and CBD. THC is the psychoactive compound in cannabis while CBD is known for its medicinal benefits. CBD is also a non-psychoactive compound and can be used for the treatment of depression, anxiety, inflammation, and seizures.

CBG has been overshadowed by these other compounds and will appear in a lower concentration when compared to THC and CBD. However, research into this compound has been increasing at a steady rate over the years. This is why you need to know more about what CBG is, how it works and what it can actually be used for.

What Is CBG?

CBG was first discovered in 1964 in Israel. At the time, Yehiel Gaoni and Raphael Mechoulam, marijuana researchers, had managed to isolate CBG along with CBD and THC. At the time, they may not have realized how important this would be. However, this discovery would go on to be the basis of our current understanding of the cannabis plant.

THC and CBD were found in higher concentrations than CBG and the latter differed from the other compounds in a number of ways. CBG, like CBD, has no psychoactive properties and will not contribute to the high feelings that you get. It is also possible to find this compound in some industrial hemp variations as well as other strains of marijuana.

While this compound has been overlooked in favor of CBD and THC, there are many beneficial properties that it has to offer. The only issue is that research into CBG is still in the early stages. However, there is no doubt that there is more to learn about this compound and what it is capable of. While the research is still ongoing, we do know how CBG works and some of the remarkable effects it has on the human body.

How Does CBG Work?

Like the other cannabinoids found in cannabis, CBG will influence the endocannabinoid system in the body. This is a complex system of CB1 and CB2 receptors, chemicals known as endocannabinoids and enzymes. The endocannabinoids are compounds that the body creates to bind with the receptors and help to regulate a number of different functions and the internal balance of the body.

CB1 receptors will be found in the brain and nervous system while the CB2 receptors are scattered throughout the body, primarily in the cells of the immune system. There are a lot of different endocannabinoids that can bind to the receptors, but the most common is anadamide as well as 2-arachidonoylglycerol. AEA will generally bind with the CB1 receptors and is similar to a neurotransmitter which affects your mood and overall cognitive function. 2-AG works with both the CB1 and CB2 receptors and will have anti-inflammatory effects.

The cannabinoids that are found in the cannabis plant will also have the ability to bind to these receptors due to the similar shape. THC will bind to the CB1 receptors and later the way that you think which causes the high. CBD does not actually bind that easily with the receptors, but it will influence how they react to other cannabinoids.

The research done on CBG has found that it primarily binds with the CB2 receptors. Additionally, when high doses are used, it will block other compounds from binding with the CB1 receptors. However, it is important to note that this does not appear to alter the effects of THC.

All of these reactions and influences between the different cannabinoids and the endocannabinoid system are called the entourage effect. Researchers are just starting to understand the full implications of this. However, it has been suggested that using cannabinoids in combination will provide better results compared to using them individually.

What Is CBG Used For?

All of the health benefits of CBG are not fully understood yet. However, the initial research which has been done has found that it is a very useful tool in the treatment of a number of psychological and physical conditions. To better understand the benefits of this compound, you will need to look at the research that has already been done.

The Anti-Inflammatory Effects

It is thought that CBG has anti-inflammatory properties. This means that it could potentially be used to help with the treatment of certain chronic diseases. One study into this compound looked at its use to treat IBD or inflammatory bowel disease.

This research found that CBG was able to reduce the inflammatory markers in mind that had induced IBD. It was also able to relieve colitis. With these findings, the authors of the study suggest that the compound be tested further with human subjects.

If these anti-inflammatory properties are confirmed, it is possible that it will have a broad application for more than the treatment of colitis. Chronic inflammation is often part of some very painful conditions such as arthritis. It has also been linked to other serious disorders such as diabetes, high blood pressure, cancer, depression, and heart disease.

This is one of the reasons why it is highly desirable to find new ways of reducing inflammation where possible. Of course, additional research will need to be completed, but cannabinoids like CBG are giving hope for new treatments.

The Neuroprotective Effects

CBG is also thought to act as an antioxidant and will help to protect the nervous system from damage. This is done in a similar way as 2-AG, an endocannabinoid. This benefit was found in another animal study where this compound was able to preserve neurons and improve motor defects in neurodegenerative diseases such as Huntington’s

The Antimicrobial Effects

Many cannabinoids, including CBG, have shown antimicrobial effects. This was tested against a few strains of the Staphylococcus aureus bacteria in a laboratory. During this testing, CBG was found to have significant antimicrobial properties and this is a finding which could be very important in the future. Antibiotic resistance is becoming more common across the globe and this property could help fight this.

CBG As An Appetite Stimulant

There have been promising results when it comes to using CBG as an appetite stimulant. A study done in 2016 gave a control group of rats a placebo and another group CBG. The rats that were given CBG increase the number of meals and doubled their overall food intake. It is important to note that the amount eaten at meals and the duration was not affected.

The researchers did not see any adverse effects in the rats that received CBG. This means that the compound could be used as a treatment for conditions like cachexia and anorexia.

CBG For Bladder Problems

In 2015, a study was done on cannabinoids and their use for treating bladder dysfunction. This study found that they have the ability to reduce bladder contractions in mice. CBG was one of the most effective compounds tested along with THCV. It has also been found that CBG offers the best reduction of these contractions in humans.

CBG For Cancer?

Due to the antioxidant and anti-inflammatory properties of CBG, this compound could also be used to fight against cancer. A study on the effect of CBG on colon cancer found that this compound was able to inhibit the growth of the cancer cells. When tested in mice, it was also found to have anti-tumoral properties. This means that it could be a potential prevention and cure for people with this disease in the future.

There have also been studies looking into cannabinoids as a treatment for breast cancer, lung cancer, prostate cancer, and bone cancer. While the initial findings from this research have been promising, there is more that needs to be done before they can be considered for any clinical trials with human subjects.

Other Uses For CBG

As CBG is still coming out of the shadow of THC and CBD, there is more to be learned about its potential advantages. However, it has been suggested that the compound could influence certain receptors in the nervous system. It is also possible that the compound can be used to help fight the symptoms of depression.

While CBG is not the most well-known of the cannabinoids, it does have a dramatic include over a number of vital systems in the body. There is still much that needs to be learned about the compound and how it will affect us. However, the initial research into this has brought many promising results.

It is clear that a lot more research needs to be done to fully understand the effect of cannabinoids on the human body and the role of the endocannabinoid system. However, this is something that we are getting closer to every day.

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